Applications of NMR Spectroscopy, Volume 1

Applications of NMR Spectroscopy, Volume 1, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of edible oils and lipid content in foods, the role of NMR spectroscopy in the human metabolomics and the diagnosis of autism-related disorders, protein-protein interactions, and NMR spectroscopy of chiral molecules.
The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications.
The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field.
Consolidates the latest developments in NMR spectroscopy into a single volume
Authored and edited by world-leading experts in spectroscopy
Features comprehensive references to the most recent related literature
More than 75 illustrations aid in the retention of key concepts
PQ001 Oil Moisture Content NMR Analyzer for Seeds

Product Description

The PQ001 NMR Analyzer was launched in 2008. After years of upgrading, PQ001 has many advantages such as small size, high precision, good repeatability, good stability and excellent cost/benefit performance. Based on these advantages, PQ001 has been widely used in the determination of oil & moisture content in food & agriculture areas.

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Basic Parameters

• Magnet type: permanent magnet
• Magnetic field intensity: 0.28±0.05T
• Probe coil: Ø40mm
• Size (LxWxH): 1685mm×520mm×386mm
• Weight: 85Kg

Flow and Diffusion Measurement with MR

Nuclear magnetic resonance (NMR) non-invasively accesses many parameters in contrast with other commonly used measurement methods, whether they are non-invasive or not.
These parameters can be divided roughly into three classes of information: chemical, physical, and spatial.Chemical includes benchtop NMR spectroscopy, the workhorse in analytical chemistry and in structural biochemistry but, to date, there has been relatively little overlap between this class and this conference.
Physical information accessible with NMR analyzer includes molecular structure, phase transition, diffusion, and flow.Both chemical and physical information can be combined with spatial information to produce maps of such information.In addition, flow and diffusion, by their nature, involve spatial information.
Such spatially resolved information is the main emphasis of this meeting.In this lecture, I shall review NMR flow and diffusion measurements.What is needed for such measurements is the presence of a known gradient of the static magnetic field strength in which the experiments are conducted.
When a nuclear spin moves in the field gradient, its precession rate changes and this can be detected to yield the displacement of the spin in the time required to do the experiment–times measured in milliseconds.The dependence of such displacements as a function of measurement time results in identification of the nature of sample motion, i. e., whether it is flow or diffusion.
We will start with basic principles and go on to examples with emphasis on gaining physical background knowledge that may aid in understanding flow and diffusion presentations during this meeting.Some references to this subject are listed below.The last three are based on previous ICMRM conferences, specifically in 1991, 1997, and 2009.

NMR Spectroscopy Explained

There is one specific area where I find this book is somewhat lacking, the discussion on T1, T2 and NOE which is fairly rudimentary. It is more than sufficient for those new to the topic or working on small molecules, but does not offer much past that in my opinion. Also, if you are looking for a better understanding in solid state NMR, this is not the book for you. I would highly recommend this book for anyone wanting to learn more about NMR analyzer.

This is the best all around benchtop NMR text I have come across. Jacobsen does a great job of explaining the vast array of topics in NMR ranging from the nuclear magnetism and pulse sequences to biological NMR. It is very well written, easy to read and follow, while still going into great amounts of detail.

For those who do not enjoy heavy amounts of differential equations and linear algebra, then you will appreciate this book as there is just enough math to aid the written explanations, but not so much as to make your head spin. This book also has one of the best explanations/discussions on multi-dimensional techniques commonly used in organic and biological chemistry.

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments.
Introduces students to modern NMR as applied to analysis of organic compounds.
Presents material in a clear, conversational style that is appealing to students.
Contains comprehensive coverage of how NMR experiments actually work.
Combines basic ideas with practical implementation of the spectrometer.
Provides an intermediate level theoretical basis for understanding laboratory experiments.
Develops concepts gradually within the context of examples and useful experiments.
Introduces the product operator formalism after introducing the simpler (but limited) vector model.

Initially I wanted to write a review for this book after I finish the whole book. However, since the publication of this book, I have noticed that nobody has ever written a review. I have only finished approximately 400 pages but I want to let people to know that this is clearest exposition on modern nmr spectroscopy I have ever come across. I have read a number of nmr books. These include the following

J.D. Roberts "ABC of FT NMR"
T. Claridge "High Resolution NMR spectroscopy in organic chemistry"
J. Sanders " Modern NMR spectroscopy"
H. Friebolin "Basic One- and Two-Dimenionsal NMR"

None of the above is as good as this book. The one that comes close to this is Friebolin's book. However, it is not as detail and does not cover topics such as operator formalism and density matrix. This book also covers the basic theoretical principles and presented in a very lucid way. I enjoy reading this book tremendously.

Dec 14, 2009. It has been almost 2 years since I wrote the initial review. Since then, I have the opportunity to read the whole book a second time. 

NMR for Novice Master and Refresher

This book clearly illustrates the major aspects of NMR spectroscopy, instrumentation and applications in a relatively simple language without the use of complicated mathematics. 

This is an impressive and detailed book for anyone who wants to know NMR analyzer. I found in this book all what I need about protein NMR from basic level up to most advanced triple-resonance experiments. This textbook (or reference book) is helpful for all levels of students and experts. After reading through the book, I feel like I am an NMR expert because the book not only teaches the new thing I did not know but also summarizes what I already knew. I showed it to my friends and they all like it just by looking at the table of contents. I totally agree with the reviewer’s comments printed on the book cover:

“This is the first totally thorough book on the subject…” by Lawrence J. Berliner, University of Denver

“While NMR treatises abound, there exists no single text that provides both the information necessary to understand the experiments and processes, as well as the practical details for their successful implementation. This considerable gap in the literature is now happily bridged by Quincy Teng’s timely contribution.” By Gerd N. La Mar, University of California, Davis.

This book clearly illustrates the major aspects of NMR spectroscopy, instrumentation and applications in a relatively simple language without the use of complicated mathematics. The questions at the end of each section reflect the main points of the contents. It can be used as a self study textbook for beginners, as well as a reference for teaching and research in NMR spectroscopy.

This textbook begins with an overview of benchtop NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

This is the first totally through book on the subject. It covers theory, the instrument, how to run an experiment, the latest in pulse and structure determination methods. The best part is that it’s written as a textbook with questions and goal at the beginning of each section and homework or exam problems. It is ideal for a graduate or advanced undergraduate course on 

biological NMR.” – Lawrence J. Berliner, University of Denver, Denver, CO, USA “While NMR treatises abound, there exists no single text that provides both the information necessary to understand the experiments and processes, as well as the practical details for their successful implementation. This considerable gap in the literature is now happily bridged by Quincy Teng’s timely contribution. 

Solid-State NMR and Polymers

Solid-state benchtop NMR now favorably competes with well-established techniques, such as light, x-ray, or neutron scattering, electron microscopy, and dielectric and mechanical relaxation.

The application of multidimensional solid-state NMR analyzer inevitably involves use of concepts from different fields of science. This book also provides the first comprehensive treatment of both the new experimental techniques and the theoretical concepts needed in more complex data analysis.

NMR spectroscopy is the most valuable and versatile analytical tool in chemistry. While excellent monographs exist on high-resolution NMR in liquids and solids, this is the first book to address multidimensional solid-state NMR.

 Multidimensional techniques enable researchers to obtain detailed information about the structure, dynamics, orientation, and phase separation of solids, which provides the basis of a better understanding of materials properties on the molecular level.Dramatic progress-much of it pioneered by the authors-has been achieved in this area, especially in synthetic polymers.

The text addresses spectroscopists and polymer scientists by treating the subject on different levels; descriptive, technical, and mathematical approaches are used when appropriate. It presents an overview of new developments with numerous experimental examples and illustrations, which will appeal to readers interested in both the information content as well as the potential of solid-state NMR.

The book also contains many previously unpublished details that will be appreciated by those who want to perform the experiments. The techniques described are applicable not only to the study of synthetic polymers but to numerous problems in solid-state physics, chemistry, materials science, and biophysics.

Key Features
* Presents original theories and new perspectives on scattering techniques
* Provides a systematic treatment of the whole subject
* Gives readers access to previously unpublished material
* Includes extensive illustrations
One of the best books on solid-state NMR currently published. The authors present a thorough overview of theory of solids NMR with the focus on applications in polymer science. Would be one of my first choices for a graduate level textbook in solid-state NMR. Targeted at an intermediate reader familiar with the basic concepts of NMR. Highly recommended

Definitely a very comprehensive textbook which treats many relevant and modern advances in the field. A must-have for every researcher in solid state NMR. Downside is that the book is written in the style of a reference book, and not really good as teaching material. But overall I give it 4 stars. Michael Mehring’s book on solid state nmr is still the best teaching manual to learn the theory.

NMR Spectroscopy

It has been almost 2 years since I wrote the initial review. Since then, I have the opportunity to read the whole book a second time. My opinion of this book remains the same. If you really want to understand NMR, you cannot go wrong with this book.

Initially I wanted to write a review for this book after I finish the whole book. However, since the publication of this book, I have noticed that nobody has ever written a review. I have only finished approximately 400 pages but I want to let people to know that this is clearest exposition on modern nmr spectroscopy I have ever come across. I have read a number of nmr books. These include the following

J.D. Roberts “ABC of FT NMR”
T. Claridge “High Resolution NMR spectroscopy in organic chemistry”
J. Sanders ” Modern benchtop NMR spectroscopy”
H. Friebolin “Basic One- and Two-Dimenionsal NMR”

None of the above is as good as this book. The one that comes close to this is Friebolin’s book. However, it is not as detail and does not cover topics such as operator formalism and density matrix. This book also covers the basic theoretical principles and presented in a very lucid way. I enjoy reading this book tremendously.

This is the best all around NMR text I have come across. Jacobsen does a great job of explaining the vast array of topics in NMR ranging from the nuclear magnetism and pulse sequences to biological NMR. It is very well written, easy to read and follow, while still going into great amounts of detail. 

For those who do not enjoy heavy amounts of differential equations and linear algebra, then you will appreciate this book as there is just enough math to aid the written explanations, but not so much as to make your head spin. This book also has one of the best explanations/discussions on multi-dimensional techniques commonly used in organic and biological chemistry. 

There is one specific area where I find this book is somewhat lacking, the discussion on T1, T2 and NOE which is fairly rudimentary. It is more than sufficient for those new to the topic or working on small molecules, but does not offer much past that in my opinion. Also, if you are looking for a better understanding in solid state NMR, this is not the book for you. I would highly recommend this book for anyone wanting to learn more about NMR.

I have read several books about NMR analyzer and practice, and this book provides by far the most lucid description of essentially all aspects of modern NMR (polarization transfer, coherence selection, cross-relaxation, exchange phenomena, solvent suppression, pulsed field gradients, triple resonance methods, residual dipolar couplings, etcetera). The book begins with a simple vector model, progresses to a product operator description, and toward the end, introduces readers to the density matrix representation. In addition to providing a strong conceptual understanding of pulse sequences and sequence modules (e.g., INEPT, DPFGSE, COSY, NOESY, ROESY, TOCSY, HSQC, HMQC, HMBC), the book also describes practical considerations like hardware, data collection, and data processing. The final chapter of the book describes the application of NMR to structural biology.

 This chapter might have benefited from a description of modern approaches for probing the dynamics of biological systems (e.g., relaxation dispersion NMR), which are one of the primary strengths of NMR compared to diffraction or microscopy for studies of biological systems. I recommend this book for any NMR user that seeks a greater conceptual understanding of the behavior and manipulation of nuclear spin states (i.e., how their NMR experiments work at the level of the ensemble of nuclear spins), and as a foundation for reading more advanced texts like those by Slichter, Abragam, Ernst, or Levitt.

Must Have for Protein NMR Spectroscopists

People who start they adventure with the protein NMR spectroscopy should learn from the old Wuthrich’s book first, which was published in 1986. Beginner should not start his adventure with the protein NMR spectroscopy from working with the multidimentional spectra only. In my opinion man should properly understand 2D NMR spectroscopy of different biomolecules first.

This book is one of the best NMR texts I have read. That being said, it is also one of the most challenging NMR texts I have read (it’s a tie between this and Intro to SSNMR by Melinda Duer). This book is definitely not a beginners book, so if you are just starting to learn about NMR buy something more basic like Spin Dynamics by Levitt or Understanding NMR analyzer by Keeler and read it first. I have yet to find a protein NMR text out there as good as this one. The detail in which Dr. Palmer goes into is fantastic while still being very understandable. More than anything I appreciate the depth in which he covers the different experiment types. This is a must have for anyone doing protein NMR work.

It covers advanced ideas. The book authors are alphabetical, and anyone in the field refers to it as the Palmer book…He sacrificed his research as an asst. prof to write such a great book. Great discussion of Bloch and how T1 and T2 were originally proposed. I recommend this book along side the Malcom Levitt book (Spin Dynamics). The amazon copy of this book has different paper than other copies in my lab. It is thicker and heavier, but better for writing on or annotating. Other copies in the lab with the older paper have a hard time writing on it. The binding is real crappy, I left it in the lab with that huge orgo encyclopedia sitting on the first 20 pages so it would stay open. I would have really appreciated a paperback version, but they don’t make one. Note there is significant differences between the first and second editions, don’t cheap out you will be sorry. Get this one.

This is the new standard for Protein NMR spectroscopists (the old one being Ernst). Everyone I’ve met who uses NMR application in biology has nothing but praise for this book. It’s not a perfect book and has some weakness, especially in the modelling portions. The math derivations are clear but the authors do not connect back to the physical phenomenon. I would recommend keeping a QM book nearby as a reference. However, this book is well written overall and very complete.

Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. The second edition includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.

Book of NMR CASE STUDIES

NMR Case Studies: Data Analysis of Complicated Molecules provides a detailed discussion of the full logical flow associated with assigning the NMR spectra of complex molecules while helping readers further develop their NMR spectral assignment skills.

The robust case studies present the logic of each assignment from beginning to end, and fully explore the available range of potential solutions. Readers will gain a better appreciation of various approaches and will develop an intuitive sense for when this particular concept should be implemented. This enhances the skill sets of readers by providing a host of methodologies potentially amenable to yielding correct assignments.

Readers will gain a better appreciation of various approaches and will develop an intuitive sense for when this particular concept should be implemented. This enhances the skill sets of readers by providing a host of methodologies potentially amenable to yielding correct assignments. Authored by a scientist with more than 20 years of experience in research and instruction, this book is the ideal reference for anyone in search of application-based content that addresses complicated molecules including corticosteroids, biomolecules, polypeptides, and secondary metabolites.

Features the nuclear magnetic resonance NMR system for EDU spectra of a number of large and interesting molecules, ranging from corticosteroids to secondary metabolites to large synthetically prepared molecules
Uses case studies to pair the spectral signals from the various sites of each molecule to their molecular counterparts in a process called assignment
Includes complex NMR system for research problems, aiding readers in the development of NMR spectral assignment skills
Features input from a leading scientist with over 20 years of research and instruction experience in the field

Authored by a scientist with more than 20 years of experience in research and instruction, this book is the ideal reference for anyone in search of application-based content that addresses complicated molecules including corticosteroids, biomolecules, polypeptides, and secondary metabolites.

Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology

I've always found NMR to be extremely difficult but when I got this book, it really helped me to understand how to read and analyze NMR spectra. I also had the great honor of having the author of this book as my professor recently and the guy really knows his stuff and is great at conveying his knowledge. So if you never understood NMR or don't really understand it that much, or just want a great book about NMR, this is the book for you and you can trust in the fact that the author knows his stuff. I know this book is costly, but trust me you won't regret it at all!

This book along with "Structure Determination of Organic Compounds" by Pretsch, Buhlmann, and Affolter and maybe "200 and More NMR experiments" by Berger and Braun are currently the only NMR books worth owning. Skip the rest.

Initially I wanted to write a review for this book after I finish the whole book. However, since the publication of this book, I have noticed that nobody has ever written a review. I have only finished approximately 400 pages but I want to let people to know that this is clearest exposition on modern nmr spectroscopy I have ever come across. I have read a number of nmr books. These include the following

J.D. Roberts "ABC of FT NMR"
T. Claridge "High Resolution NMR spectroscopy in organic chemistry"
J. Sanders " Modern NMR spectroscopy"
H. Friebolin "Basic One- and Two-Dimenionsal NMR"

None of the above is as good as this book. The one that comes close to this is Friebolin's book. However, it is not as detail and does not cover topics such as operator formalism and density matrix. This book also covers the basic theoretical principles and presented in a very lucid way. I enjoy reading this book tremendously.

Dec 14, 2009. It has been almost 2 years since I wrote the initial review. Since then, I have the opportunity to read the whole book a second time. My opinion of this book remains the same. If you really want to understand NMR, you cannot go wrong with this book.

I've been working with NMR analyzer for over 11 years and over the years have acquired numerous books on the subject. This book is hands down the best on the subject. The author clearly explains everything, where other books throw up a graph/spectrum/equation and expect you to figure it out magically at times. Areas I've been confused on for years suddenly all make sense.